The biochemistry, epigenetics and nutrigenomics of micro-nutrient supplementation is EXTREMELY complex and often has to be tailored to individuals. It is easy to get carried away with details and “more is better”, which is not true. Also, keep in mind that the World Cancer Research Foundation, in a VERY extensive review, recommends that all nutrients come from food. The reason for this is Mother Nature is smarter than nutriceutical manufacturers. A nutrient filled whole food diet is the best baseline, beyond which some tweaking MAY be beneficial, rather than a baseline poor diet supplemented with nutriceuticals.